Chondrometrics GmbH was founded in 2003 by Prof. Dr. med. Felix Eckstein and Prof. Dr. med Reinhard Putz, as a spin-off from the Ludwig-Maximilians Universität München (Munich, Germany). In 2004 the company transitioned to its current location in Ainring (Germany), near the border to Salzburg (Austria).
Chondrometrics is a leading provider of medical image analysis services to researchers in academia and in the pharmaceutical industry. The focus of the company is on quantitative analysis of articular cartilage, meniscus, and muscle from magnetic resonance images (MRI), and on the research of osteoarthritis.
The company has developed a highly efficient software platform and has formed a team of well-trained and highly experienced readers, to provide quantitative imaging surrogates of tissue adaptation and disease progression in large scale studies.
Representatives of the company are actively involved in academic research and publish continuously and extensively in the biomedical literature. The purpose of these activities is to provide and validate novel quantitative image analysis methodologies, to gain a better understanding of musculoskeletal disease pathogenesis, and to help companies to detect therapeutic drug effects earlier and with greater efficiency than currently possible based on traditional methodologies.
Chondrometrics GmbH provides expert consultation and image analysis service to academic researchers and the pharmaceutical industry. The strength of Chondrometrics, we believe, lies in the dedication and experience of its team of specialized researchers and readers, the profound integration with the scientific community, the rigorous scientific validation of its methodologies, and the transparency of its technology by publication in leading scientific journals. At Chondrometrics, we value our clients as collaborators, react immediately to their requests and specific needs, provide validated scientific information, communicate promptly, and act with anticipation.
Felix Eckstein, born 1964 in Freiburg, Germany studied Medicine in Freiburg and Heidelberg, where he graduated in 1991. In 1987 he received a scholarship from the German Academic Exchange Service (DAAD) to study Medicine at Bristol University (U.K.), and in 1988 a scholarship from the Dr. Carl Duisberg Stiftung to complete his doctoral thesis at the University of Innsbruck (Austria). In 1990, Felix Eckstein completed electives at the Hotel Dieu in Paris (Surgery) and at the Centre Gui de Chauliac in Montpellier, France (Neurology).
In 1991, Felix Eckstein joined the research group led by Prof. Reinhard Putz at the Institute of Anatomy at the Ludwig-Maximilians-University (LMU), Munich, Germany to work on joint morphology and mechanics. In 1993 he joined the Institute of Diagnostic Imaging at the LMU to start his work on quantitative magnetic resonance imaging of articular cartilage. He became an assistant professor at the Institute of Anatomy at LMU in 1994 and lecturer of Anatomy in 1997.
In 2003, Felix Eckstein founded Chondrometrics GmbH, a spin-off company from the LMU Munich that produces and licenses software for cartilage segmentation and quality-controlled data analysis. The company provides image analysis service for academic researchers and the pharmaceutical industry. In 2004, Felix Eckstein became Professor of Anatomy and Director of the Institute of Anatomy and Musculoskeletal Research at the Paracelsus Medical University (PMU) in Salzburg. At the PMU his team is responsible for teaching Anatomy in the preclinical curriculum and for running a comprehensive postgraduate surgical course system. The research by Felix Eckstein’s team focuses on the integration of imaging methods for understanding the morphology, function and disease of musculoskeletal tissues, in particular osteoarthritis and osteoporosis. Felix Eckstein has authored more than 100 peer-reviewed international journal articles and more than 20 review articles and book chapters in the field of cartilage and bone research.
Felix Eckstein has been president of the German Society of Biomechanics (DGfB) from 2002 to 2003, board member of the DGfB from 2000 to 2005, Secretary General of the Osteoarthritis Research Society International (OARSI) in 2005 and 2006, and is currently board member of OARSI. He is chair of the OARSI Outreach Committee.
In June 2007, Felix Eckstein organized the 1st OARSI Osteoarthritis Imaging Workshop in Ainring (Germany), with 126 registered participants from academia, regulatory and funding agencies, and industry. He was co-organizer of the 2nd OARSI Imaging Workshop in Boston (MA) in June 2008, of the 3rd Workshop in York (England) in May 2009, and is organizer of the 5th Workshop in June 2011 in Salzburg, Austria.
In September 2010, Felix Eckstein received the “Clinical Research Award” of the Osteoarthritis Research Society International (OARSI), which was granted to him at the World Congress of Osteoarthritis in Brussels, Belgium Felix Eckstein serves on the editorial board of Osteoarthritis and Cartilage, and is Associate Editor of Cell Tissue Organs and Annals of Anatomy.
Professor Reinhard Putz was born in Innsbruck/Austria on August 5, 1942. After studying medicine and gaining an MD degree in 1968, he became Assistant Professor at the University of Innsbruck Institute of Anatomy, where he completed his postdoctoral thesis (“Habilitation”) in 1979. After research stays in Munich and Freiburg/Germany, Professor Putz became Director of the Institute of Anatomy at Albert-Ludwigs-Universität Freiburg. In 1989, Professor Putz was appointed Director of the Institute of Anatomy at Ludwig-Maximilians-Universität (LMU) München. Between 2003 and 2010 he served Vice- President of LMU. Professor Putz retired from his academic positions in September 2010. In 2003, Professor Putz was a cofounder of Chondrometrics GmbH and since serves as Vice President of the company.
Professor Putz’s research focuses on the biomechanics of the skeletal system, especially the formfunction relationship of the joints and the spine. He has also addressed various topics concerning clinical anatomy and general aspects of medical education, leading to approximately 250 publications and more than oral 450 presentations. Professor Putz was instrumental in producing a series of anatomy textbooks with international circulation (e.g. Sobotta, Atlas of Anatomy). Reinhard Putz was engaged in a series of scientific journals and serves as Associate Editor of Advances in Anatomy, Histology and Embryology.
Reinhard Putz was president of the European Association of Clinical Anatomy (EACA) form 1991 to 1993, Associate Secretary General of EACA from 1993 to 2003, Vice-President of the German Society of Biomechanics (DGfB) 1997-1999, member of the board of the “Anatomische Gesellschaft” from 1998 to 2002, member of the board of the German Reunion of Medical Schools from 2003 to 2006. He was a reviewer of the German Research Foundation from 1996 to 2004 and member of the Board of National Medical Examination (part 1) from 1993 to 2003. Since 2009 Reinhard Putz is member of the board of governors of Medical University of Innsbruck/Austria.
The academic work of Professor Reinhard Putz has been recognized in the form of numerous national and international awards and prizes. These include an honorary degree from the University of Constanta (Romania) and membership in the German National Academy of Sciences Leopoldina and the European Academy of Sciences and Arts. He also received the Friedrich-Pauwels Medal of the German Society of Orthopedics, and the Ars Legendi award by the German Rectors’ Conference and Donor’s Association for German Science for “Excellence in teaching“ and for organising a new master program (“Master of Medical Education”) together with the University of Heidelberg.
Wolfgang Wirth was born 1980 in Fürstenfeldbruck, Germany, and studied Computer Science at the Technical University of Munich (TUM) between 2000 and 2006. While studying at the TUM, Wolfgang Wirth was a co-founder of BitoS GmbH in 2004, a company focusing on mobile applications. In 2003, Wolfgang Wirth became a free-lancer at Chondrometrics GmbH, for which he develops software applications for quality control, segmentation and quantitative analysis of anatomical structures, including cartilage, meniscus and muscle.
He completed his master thesis titled “Automatic detection of subregions in cartilage plates for the quantitative analysis in osteoarthritis patients” and graduated with a “Master of Science” degree in “Computer Science” from TUM in 2006.
From 2007, Wolfgang Wirth worked at the Institute of Anatomy of the Ludwig-Maximilians-University (LMU) in Munich, Germany in the research group led by Prof. Reinhard Putz. Professor Putz also was supervisor for his PhD doctoral thesis titled “Longitudinal Analysis of Cartilage Morphology in Subregions of Knee Osteoarthritis Patients”.
Since 2009, Wolfgang Wirth works at the “Institute of Anatomy and Musculoskeletal Research” at Paracelsus Medical University (PMU) in Salzburg, Austria, led by Prof. Felix Eckstein. In 2010, Wolfgang Wirth became co-owner of Chondrometrics GmbH and is responsible for the IT infrastructure, software development, and quality management in the company. Wolfgang Wirth has authored and co-authored more than 100 original scientific papers in leading scientific journals.
Susanne Maschek was born in Munich, Germany, August 1966. She studied Veterinary Medicine at the LMU Munich, Germany and graduated in 1995.
From 1995 to 1997 Susanne Maschek worked with the group of Prof. Fritz Grimm at the Institute of Avian Medicine of the LMU, Oberschleißheim, Germany for her PhD doctoral thesis titled "Studies of Heavy Metal Toxification in Predatory Birds, and Multi-Element Analyses Using Neutron Activation Analysis in Feathers". She performed the neutron activation analysis at the Research Reactor Center of the Department of Physics, TUM, Garching under the guidance of Prof. Schreckenbach, where she had a part time appointment. Susanne Maschek also worked as substitute in several veterinary surgeries during this period.
From 1999 on she was employed in a veterinary surgery, Oberaichbach, Germany, with focus on tall animals (cattle, horses) and birds until her parental leave (2001 to 2003).
Since January 2004 Susanne Maschek is working as freelancer at Chondrometrics GmbH. She performs segmentation of articular cartilage, is responsible for supervision and quality control of quantitative readings, as well as for the training and education of technicians. Since 2010 she is coowner of Chondrometrics GmbH.
Susanne Maschek also performs segmentation and quality control readings as a freelancer for the "Institute of Anatomy and Musculoskeletal Research" of the Paracelsus Medical University (PMU) in Salzburg, Austria.
Eckstein F, Buck R, Wirth W
Location-independent analysis of structural progression of osteoarthritis-taking it all apart, and putting the puzzle back together makes the difference
Seminars in Arthritis and Rheumatism 46(4):404-410 (2017)
Guerrero Y, Soomro N, Wilson G, Dam Y, Meiklejohn J, Simpson K, Smith R, Brand-Miller
J, Simic M, O'Connor H, Mavros Y, Foroughi N, Poon T, Bradshaw K,
March L, Vanwanseele B, Eckstein F, Fransen M, Bergamasco J, Anandacoomarasamy
A, Singh MF
Train high eat low for Osteoarthritis study (THE LO study): protocol for a randomized controlled trial.
Journal of Physiotherapy 61:217 (2015)
Willie B, Pap T, Perka C, Schmidt C, Eckstein F, Arampatzis A, Hege H, Madry H, Vortkamp
A, Duda G
Overload of joints and its role in osteoarthritis: Towards understanding and preventing progression of primary osteoarthritis.
Rheumatology 74:618-621 (2015)
Eckstein F, Guermazi A, Gold G, Duryea J, Hellio Le Graverand M.-P, Wirth W, Miller
Imaging of cartilage and bone: promises and pitfalls in clinical trials of osteoarthritis.
Osteoarthritis and Cartilage 22:1516-1532 (2014)
Roemer FW, Eckstein F, Hayashi D, Guermazi A
The role of imaging in osteoarthritis.
Best Practice and Research in Clinical Rheumatology 28:31-60 (2014)
Eckstein F, Kwoh CK, Link TM; for the OAI investigators
Imaging research results from the Osteoarthritis Initiative (OAI): a review and lessons learned 10 years after start of enrolment.
Annals of Rheumatic Diseases 73:1289-3000 (2014)
Eckstein F, Kwoh K
Imaging in Rheumatology in 2013: From images to data to theory
Nature Reviews Rheumatology 10:69-70 (2014)
Guermazi A, Hayashi D, Eckstein F, Hunter DJ, Duryea J, Roemer FW
Imaging of osteoarthritis.
Rheumatic Disease Clinics of North America 39:67-105 (2013)
Hunter DJ, Eckstein F, Kraus VB, Losina E, Sandell L, Guermazi A
Imaging biomarker validation and qualification report: Sixth OARSI Workshop on Imaging in Osteoarthritis combined with third OA Biomarkers Workshop.
Osteoarthritis and Cartilage 21:939-942 (2013)
Eckstein F, Wirth W, Nevitt MC
Recent advances in osteoarthritis imaging - the Osteoarthritis Initiative
Nature Reviews Rheumatology 8:622-630 (2012)
Eckstein F, Wirth W
Quantitative cartilage imaging in knee osteoarthritis
Arthritis 2011 Article ID 475684 doi:10.1155/2011/475684
Hunter DJ, Eckstein F
From joint anatomy to clinical outcomes in osteoarthritis and cartilage repair: summary of the fifth annual osteoarthritis imaging workshop.
Osteoarthritis and Cartilage 19:1263-1269 (2011)
Hunter DJ, Arden N, Conaghan PG, Eckstein F, Gold G, Grainger A, Guermazi A, Harvey
W, Jones G, Hellio Le Graverand MP, Laredo JD, Lo G, Losina E, Mosher
TJ, Roemer F, Zhang W; on behalf of the OARSI OA Imaging Working
Definition of osteoarthritis on MRI: result of a Delphi exercise
Osteoarthritis and Cartilage 19:963-969 (2011)
Quantitative morphological imaging of the knee joint.
In: Advances in MRI of the knee for Osteoarthritis: World Scientific (2010)
Roemer FW, Eckstein F, Guermazi A
Magnetic resonance imaging-based semiquantitative and quantitative assessment in osteoarthritis.
Rheumatic Diseases Clinics of North America 35(3):521-55 (2009)
Trattnig S, Domayer S, Welsch GW, Mosher T, Eckstein F
MR imaging of cartilage and its repair in the knee ? a review.
European Radiology 19(7):1582-94 (2009)
Eckstein F, Guermazi A, Roemer FW
Quantitative MR imaging of cartilage and trabecular bone in osteoarthritis
Radiologic Clinics of North America 47(4): 655-73 (2009)
Hunter DJ, Le Graverand MP, Eckstein F
Radiologic makers of osteoarthritis progression.
Current Opinion in Rheumatology 21(2):110-7 (2009)
Hunter DJ, Eckstein F
Exercise and osteoarthritis.
Journal of Anatomy 214(2):197-207 (2009)
Guermazi A, Eckstein F, Hellio Le Graverand-Gastineau MP, Conaghan PG, Burstein D,
Keen H, Roemer FW
Osteoarthritis: current role of imaging.
The Medical Clinics of North America 93(1):101-26 (2009)
Guermazi A, Burstein D, Conaghan P, Eckstein F, Hellio Le Graverand-Gastineau MP,
Keen H, Roemer FW
Imaging in osteoarthritis.
Rheum Dis Clin North Am 2008 34(3):645-87 (2008)
Augat P, Eckstein F
Quantitative imaging of musculoskeletal tissue.
Ann Rev Biomed Eng. 10:369-90 (2008)
Eckstein F, Mosher T, Hunter D
Imaging of knee osteoarthritis: data beyond the beauty.
Current Opinion Rheumatol. 19(5):435-443 (2007)
Future directions in quantitative imaging of osteoarthritis.
European Musculoskeletal Review,Touch Briefings: London (2007)
Quantitative magnetic resonance imaging of osteoarthritis.
Future Medicine 1 (6): 699-715 (2006)
Eckstein F, Burstein D, Link TM
Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis.
NMR in Biomedicine 19 (7): 822-854 (2006)
Eckstein F, Hudelmaier M, Putz R
The effects of exercise on human articular cartilage.
Journal of Anatomy 208(4): 491-512 (2006)
Eckstein F, Cicuttini F, Raynauld J-P, Waterton J C, Peterfy C
Magnetic resonance imaging (MRI) of articular cartilage in knee osteoarthritis (OA): morphological assessment.
Osteoarthritis and Cartilage 14 Suppl A: A46-75 (2006)
Peterfy CG, Gold G, Eckstein F, Cicuttini F, Dardzinski B, Stevens R
MRI protocols for whole-organ assessment of the knee in osteoarthritis.
Osteoarthritis and Cartilage 14 Suppl A:A95-111 (2006)
Glüer CC, Barkmann R, Hahn HK, Majumdar S, Eckstein F, Nickelsen TN, Bolte H, Dicken
V, Heller M
Parametric biomedical imaging--what defines the quality of quantitative radiological approaches?
Röfo 178(12):1187-201 (2006)
Ateshian G, Eckstein F
Quantitative anatomy of diarthrodial joint articular layers.
In: Basic Orthopaedic Biomechanics and Mechano-Biology, 3rd edition.
Lippincott; Raven; Philadelphia, New York (2005)
Gray ML, Eckstein F, Peterfy C, Dahlberg L, Kim YJ, Sorensen AG, Smith RL
Toward imaging biomarkers for osteoarthritis.
Clinical Orthopaedics and Related Research 427 (Suppl): S175-181 (2004)
Eckstein F, Glaser C
Measuring cartilage morphology with quantitative magnetic resonance imaging.
Seminars Musculoskeletal Radiology 8: 329-353 (2004)
Noninvasive study of human cartilage structure by MRI.
Methods Mol Med. 101:191-218 (2004)
Eckstein F, Englmeier K-H, Reiser M, Putz R
In vivo morphometry and functional analysis of human articular cartilage with quantitative magnetic resonance imaging? From image to data, from data to theory.
Anatomy and Embryology 203: 147-173 (2001)
Eckstein F, Jacobs C, Merz B
Effects of joint incongruity on articular pressure distribution and subchondral bone remodelling.
Advances in Anatomy, Embryology and Cell Biology Vol. 152 (2000)
Eckstein F, Maschek S, Roemer FW, Duda GN, Sharma L, Wirth W
Cartilage loss in radiographically normal knees depends on radiographic status of the contralateral knee - data from the Osteoarthritis Initiative.
Osteoarthritis and Cartilage. 2018
Deveza LA, Downie A, Tamez-Peña JG, Eckstein F, Van Spil WE, Hunter DJ
Trajectories of femorotibial cartilage thickness among persons with or at risk of knee osteoarthritis: development of a prediction model to identify progressors.
Osteoarthritis and Cartilage. 2018
Meng T, Venn A, Eckstein F, Wirth W, Cicuttini F, March L, Dwyer T, Cross M, Laslett
LL, Jones G, Ding C, Antony B
Association of adiposity measures in childhood and adulthood with knee cartilage thickness, volume and bone area in young adults.
International journal of obesity and related metabolic disorders (Epub ahead of print)
Bricca A, Wirth W, Juhl CB, Kemnitz J, Hunter DJ, Kwoh CK, Eckstein F, Culvenor A
Moderate physical activity may prevent cartilage loss in women with knee osteoarthritis: data from the Osteoarthritis Initiative.
Arthritis Care and Research (Epub ahead of print)
Jafarzadeh SR, Clancy M, Li JS, Apovian CM, Guermazi A, Eckstein F, Felson DT
Changes in the structural features of osteoarthritis in a year of weight loss.
Osteoarthritis and Cartilage 26(6):775-782 (2018)
Chaudhari AS, Black MS, Eijgenraam S, Wirth W, Maschek S, Sveinsson B, Eckstein F,
Oei EHG, Gold GE, Hargreaves BA
Five-minute knee MRI for simultaneous morphometry and T(2) relaxometry of cartilage and meniscus and for semiquantitative radiological assessment using double-echo in steady-state at 3T.
Journal of Magnetic Resonance Imaging 47(5):1328-1341 (2018)
Wirth W, Hunter DJ, Nevitt MC, Sharma L, Kwoh CK, Ladel C, Eckstein F
Predictive and concurrent validity of cartilage thickness change as a marker of knee osteoarthritis progression: data from the Osteoarthritis Initiative.
Osteoarthritis and Cartilage 25(12): 2063-2071 (2017)
Buck RJ, Le Graverand MH, Wirth W, Eckstein F
Choice of knee cartilage thickness change metric for different treatment goals in efficacy studies.
Seminars in Arthritis and Rheumatism 46(4):404-410 (2017)
van der Woude JAD, Wiegant K, van Roermund PM, Intema F, Custers RJH, Eckstein F,
van Laar JM, Mastbergen SC, Lafeber FPJG
Five-year follow-up of knee joint distraction: clinical benefit and cartilaginous tissue repair in an open uncontrolled prospective study.
Cartilage 8(3):263-271 (2017)
Wirth W, Maschek S, Eckstein F
Sex- and age-dependence of region- and layer-specific knee cartilage composition (spin-spin-relaxation time) in healthy reference subjects.
Annals of Anatomy 210:1-8 (2017)
Moyer R, Wirth W, Eckstein F
Longitudinal changes in MRI-based measures of femorotibial cartilage thickness as a function of alignment and obesity data from the OAI.
Arthritis Care and Research 69(7):959-965 (2017)
Wirth W, Maschek S, Roemer FW, Eckstein F
Layer-specific femorotibial cartilage T2 relaxation time in knees with and without early knee osteoarthritis:Data from the Osteoarthritis Initiative (OAI).
Scientific Reports 6:34202 (2016)
Kwee RM, Wirth W, Hafezi-Nejad N, Zikria BA, Guermazi A, Demehri S
Role of physical activity in cartilage damage progression of subjects with baseline full-thickness cartilage defects in medial tibiofemoral compartment: data from the Osteoarthritis Initiative.
Osteoarthritis and Cartilage 24(11):1898-1904 (2016)
Roemer FW, Aydemir A, Lohmander S, Crema MD, Marra MD, Muurahainen N, Felson DT,
Eckstein F, Guermazi A
Structural effects of sprifermin in knee osteoarthritis: a post-hoc analysis on cartilage and non-cartilaginous tissue alterations in a randomized controlled trial.
BMC Musculoskeletal Disorders 17:267 (2016)
van der Woude JA, van Heerwaarden RJ, Spruijt S, Eckstein F, Maschek S, van Roermund
PM, Custers RJ, van Spil WE, Mastbergen SC, Lafeber FP
Six weeks of continuous joint distraction appears sufficient for clinical benefit and cartilaginous tissue repair in the treatment of knee osteoarthritis.
Roemer FW, Kwoh CK, Hannon MJ, Hunter DJ, Eckstein F, Grago J, Boudreau RM, Englund
A Partial meniscectomy is associated with increased risk of incident radiographic osteoarthritis and worsening cartilage damage in the following year.
European Radiology 27(1):404-413 (2016)
Moyer R, Wirth W, Duryea J, Eckstein F
Anatomical alignment, but not goniometry, predicts femorotibial cartilage loss as well as mechanical alignment.
Data from the Osteoarthritis Initiative. Osteoarthritis and Cartilage 24(2):254-261 (2016)
Eckstein F, Boudreau R, Wang Z, Hannon MJ, Duryea J, Wirth W, Cotofana S, Guermazi
A, Roemer F, Nevitt M, John MR, Ladel C, Sharma L, Hunter DJ,
Kwoh CK; OAI Investigators
Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: A longitudinal case-control study from the Osteoarthritis Initiative.
European Radiology 26(6):1942-1951(2016)
Huang C, Shan L, Charles C, Wirth W, Niethammer M, Zhu H
Diseased region detection of longitudinal knee magnetic resonance imaging data.
IEEE Transactions on Medical Imaging 34:1914-1912 (2015)
Eckstein F, Collins JE, Nevitt MC, Lynch JA, Kraus V, Katz JN, Losina E, Wirth W,
Guermazi A, Roemer FW, Hunter DJ; FNIH OA Biomarkers Consortium
Cartilage thickness change as an imaging biomarker of knee osteoarthritis progression - data from the OA biomarkers consortium.
Arthritis and Rheumatology 67: 3184-3189 (2015)
Ried JS, Flechsenhar K, Bartnik E, Crowther D, Dietrich A, Eckstein F
Sample size calculations for detecting DMOAD effects on knee replacement in clinical trials - data from the Osteoarthritis Initiative.
Arthritis and Rheumatology 67:3174-3183 (2015)
Roth M, Emmanuel K, Wirth W, Kwoh CK, Hunter DJ, Eckstein F
Sensitivity to change and association of three-dimensional meniscal measures with radiographic joint space width loss in rapid clinical progression of knee osteoarthritis.
European Radiology 28(5):1844-1853 (2018)
Roemer FW, Kwoh CK, Hannon MJ, Hunter DJ, Eckstein F, Grago J, Boudreau RM, Englund
A Partial meniscectomy is associated with increased risk of incident radiographic osteoarthritis and worsening cartilage damage in the following year.
European Radiology 27(1):404-413 (2017)
Roth M, Wirth W, Emmanuel K, Culvenor AG, Eckstein F
The contribution of 3D quantitative meniscal and cartilage measures to variation in normal radiographic joint space width - Data from the Osteoarthritis Initiative healthy reference cohort
European Journal of Radiology 87:90-98 (2017)
Emmanuel K, Quinn E, Niu J, Guermazi A, Roemer F, Wirth W, Eckstein F, Felson D
Quantitative measures of meniscus extrusion predict incident radiographic knee osteoarthritis - data from the Osteoarthritis Initiative.
Osteoarthritis and Cartilage 24 (2):262-269 (2016)
Bloecker K, Wirth W, Guermazi A, Hunter DJ, Resch H, Hochreiter J, Eckstein F
Medial meniscal extrusion relates to cartilage loss in specific femorotibial subregions- data from the osteoarthritis initiative.
Arthritis Care and Research 67:1545-1522 (2015)
Bloecker K, Wirth W, Guermazi A, Hitzl W, Hunter DJ, Eckstein F
Longitudinal change in quantitative meniscus measurements in knee osteoarthritis-data from the Osteoarthritis Initiative.
European Radiology 25:2960-2968 (2015)
Bruns K, Svensson F, Turkiewicz A, Wirth W, Guermazi A, Eckstein F, Englund M
Meniscus body position and its change over four years in asymptomatic adults: a cohort study using data from the Osteoarthritis Initiative (OAI).
BMC Musculoskeletal Disorders 15:32 (2014)
Bloecker K, Guermazi A, Wirth W, Kwoh CK, Resch H, Hunter DJ, Eckstein F;
for the OAI investigators Correlation of semiquantitative vs quantitative MRI meniscus measures in osteoarthritic knees: results from the Osteoarthritis Initiative.
Skeletal Radiology 43:227-232 (2014)
Bloecker K, Wirth W, Hunter DJ, Duryea J, Guermazi A, Kwoh CK, Resch H, Eckstein
Contribution of regional 3D meniscus and cartilage morphometry by MRI to joint space width in fixed flexion knee radiography - A between-knee comparison in subjects with unilateral joint space narrowing.
European Journal of Radiology 82:e832-839 (2013)
Wenger A, Wirth W, Hudelmaier M, Noebauer-Huhmann I, Trattnig S, Bloecker K, Frobell
RB, Kwoh K, Eckstein F, Englund M
Meniscus body position, size and shape in persons with and without radiographic knee osteoarthritis: Quantitative analyses of knee MRIs from the Osteoarthritis Initiative.
Arthritis and Rheumatism 65:1804-1811(2013)
Bloecker K, Guermazi A, Wirth W, Benichou O, Kwoh CK, Hunter DJ, Englund M, Resch
H, Eckstein F
Tibial coverage, meniscus position, size and damage in knees discordant for joint space narrowing - data from the Osteoarthritis Initiative.
Osteoarthritis and Cartilage 21:419-427 (2013)
Wenger A, Englund M, Wirth W, Hudelmaier M, Kwoh K, Eckstein F; for the OAI Investigators.
Relationship of 3D meniscal morphology and position with knee pain in subjects with knee osteoarthritis: a pilot study.
European Radiology 22:211-220 (2012)
Siorpaes K, Wenger A, Bloecker K, Wirth W, Hudelmaier M, Eckstein F
Interobserver reproducibility of quantitative meniscus analysis using coronal multiplanar DESS and IWTSE MR imaging.
Magnetic Resonance in Medicine 67:1419-1426 (2012)
Bloecker K, Wirth W, Hudelmaier M, Burgkart R, Frobell R, Eckstein F
Morphometric differences between the medial and lateral meniscus in healthy men ? A three-dimensional analysis using magnetic resonance imaging.
Cells Tissues Organs 195:353-364 (2012)
Bloecker K, Englund M, Wirth W, Hudelmaier M, Burgkart R, Frobell RB, Eckstein F
Size and position of the healthy meniscus, and its correlation with sex, height, weight, and bone area- a cross-sectional study.
BMC Musculoskeletal Disorders 12:248 (2011)
Wirth W, Frobell RB, Souza RB, Li X, Wyman BT, Le Graverand MP, Link TM, Majumdar
S, Eckstein F
A three-dimensional quantitative method to measure meniscus shape, position, and signal intensity using MR images: a pilot study and preliminary results in knee osteoarthritis.
Magnetic Resonance in Medicine 63(5):1162-71 (2010)
Chang A, Moisio K, Chmiel JS, Eckstein F, Guermazi A, Almagor O, Cahue S, Wirth W,
Prasad P, Sharma L
Subregional effects of meniscal tears on cartilage loss over 2 years in knee osteoarthritis.
Annals of Rheumatic Diseases 70(1): 74-9 (2011)
Vanwanseele B, Eckstein F, Smith RM, Lange AK, Foroughi N, Baker MK, Shnier R, Fiatarone
The relationship between knee adduction moment and cartilage and meniscus morphology in women with osteoarthritis.
Osteoarthritis and Cartilage 18(7):894-901 (2010)
Crema MD, Guermazi A, Li L, Nogueira-Barbosa MH, Marra MD, Roemer FW, Eckstein F,
Hellio Le Graverand MP, Wyman BT, Hunter DJ
The association of prevalent medial meniscal pathology with cartilage loss in the medial tibiofemoral compartment over a 2-year period.
Osteoarthritis and Cartilage 18(3):336-43 (2010)
Hunter DJ, Buck R, Vignon E, Eckstein F, Brandt K, Mazzuca SA, Wyman BT, Otterness
I, Hellio Le Graverand MP
Relation of regional articular cartilage morphometry and meniscal position by MRI joint space width in knee radiographs.
Osteoarthritis and Cartilage 17(9):1170-6 (2009)
Sharma L, Eckstein F, Song J, Guermazi A, Prasad P, Kapoor D, Cahue S, Marshall M,
Hudelmaier M, Dunlop D
Relationship of meniscal damage, meniscal extrusion, malalignment, and joint laxity to subsequent cartilage loss in osteoarthritic knees.
Arthritis and Rheumatism 58:1716-26 (2008)
Kemnitz J, Wirth W, Eckstein F, Culvenor AG
The role of thigh muscle and adipose tissue in knee osteoarthritis progression in women: data from the Osteoarthritis Initiative.
Osteoarthritis and Cartilage 26(9):1190-1195 (2018)
Culvenor AG, Felson DT, Wirth W, Dannhauer T, Eckstein F
Is local or central adiposity more strongly associated with incident knee osteoarthritis than the body mass index in men or women?
Osteoarthritis and Cartilage 26(8):1033-1037(2018)
Steidle-Kloc E, Dannhauer T, Wirth W, Eckstein F
Responsiveness of infrapatellar fat pad volume change to body weight loss or gain: Data from the Osteoarthritis Initiative.
Cells Tissues Organs 205(1):53-62 (2018)
Culvenor AG, Hamler FC, Kemnitz J, Wirth W, Eckstein F
Brief report: Loss of muscle strength prior to knee replacement: a question of anatomic cross-sectional area or specific strength?
Arthritis and Rheumatology 70(2):222-229 (2018)
Steidle-Kloc E, Culvenor AG, Dörrenberg J, Wirth W, Ruhdorfer A, Eckstein F
Relationship between knee pain and infra-patellar fat pad morphology - A within- and between-person analysis from the Osteoarthritis Initiative.
Arthritis Care and Research 70(4):550-557 (2018)
Kemnitz J, Wirth W, Eckstein F, Ruhdorfer A, Culvenor AG
Longitudinal change in thigh muscle strength prior to and concurrent with symptomatic and radiographic knee osteoarthritis progression: data from the Osteoarthritis Initiative.
Osteoarthritis and Cartilage 25(10):1633-1640 (2017)
Burda B, Steidle-Kloc E, Dannhauer T, Wirth W, Ruhdorfer A, Eckstein F
Variance in infra-patellar fat pad volume: Does the body mass index matter? - Data from osteoarthritis initiative participants without symptoms or signs of knee disease.
Annals of Anatomy 213:19-24 (2017)
Kemnitz J, Eckstein F, Culvenor AG, Ruhdorfer A, Dannhauer T, Ring-Dimitriou S, Sänger
AM, Wirth W
Validation of an active shape model-based semi-automated segmentation algorithm for the analysis of thigh muscle and adipose tissuecross-sectional areas.
MAGMA 30(5):489-503 (2017)
Pogacnik Murillo AL, Eckstein F, Wirth W, Beavers D, Loeser RF, Nicklas BJ, Mihalko
SL, Miller GD, Hunter DJ, Messier SP
Impact of diet and/or exercise intervention on infrapatellar fat pad morphology: secondary analysis from the intensive diet and exercise for Arthritis (IDEA) Trial.
Cells Tissues Organs 203(4):258-266 (2017)
Ruhdorfer A, Haniel F, Petersohn T, Dörrenberg J, Wirth W, Dannhauer T, Hunter DJ,
Between-group differences in infra-patellar fat pad size and signal in symptomatic and radiographic progression of knee osteoarthritis vs non-progressive controls and healthy knees - data from the FNIH Biomarkers Consortium Study and the Osteoarthritis Initiative.
Osteoarthritis and Cartilage 25(7):1114-1121 (2017)
Culvenor AG, Boeth H, Diederichs G, Wirth W, Duda G, Eckstein F
Longitudinal bone, muscle and adipose tissue changes in physically active subjects - sex differences during adolescence and maturity.
Journal of Musculoskeletal and Neuronal Interactions 16(3): 237-246 (2016)
Steidle-Kloc E, Wirth W, Ruhdorfer A, Dannhauer T, Eckstein F
Intra- and inter-observer reliability of quantitative analysis of the infra-patellar fat pad and comparison between fat- and non-fat-suppressed imaging-Data from the Osteoarthritis Initiative.
Annals of Anatomy 204:29-35 (2016)
Ruhdorfer A, Wirth W, Dannhauer T, Eckstein F
Longitudinal (4 year) change of thigh muscle and adipose tissue distribution in chronically painful vs painless knees - data from the Osteoarthritis Initiative.
Osteoarthritis and Cartilage 23: 1348-1356 (2015)
Dannhauer T, Ruhdorfer A, Wirth W, Eckstein F
Quantitative relationship of thigh adipose tissue with pain, radiographic status, and progression of knee osteoarthritis: longitudinal findings from the Osteoarthritis Initiative.
Investigative Radiology 50:268-274 (2015)
Diepold J, Ruhdorfer A, Dannhauer T, Wirth W, Steidle E, Eckstein F
Sex-differences of the healthy infra-patellar (Hoffa) fat pad in relation to intermuscular and subcutaneous fat content - Data from the Osteoarthritis Initiative
Annals of Anatomy 200:30-36 (2015)
Ruhdorfer A, Dannhauer T, Wirth W, Cotofana S, Roemer F, Nevitt M, Eckstein F, for
the OAI investigators
Thigh muscle cross-sectional areas and strength in knees with early vs knees without radiographic knee osteoarthritis: a between-knee, within-person comparison.
Osteoarthritis and Cartilage 22:1634-1638 (2014)
Sattler M, Dannhauer T, Ring-Dimitriou S, Sänger AM, Wirth W, Hudelmaier M, Eckstein
Relative distribution of quadriceps head anatomical cross-sectional areas and volumes - sensitivity to pain and to training intervention.
Annals of Anatomy 196:464-470 (2014)
Ruhdorfer A, Wirth W, Hitzl W, Nevitt M, Eckstein F; for the OAI investigators
Thigh muscle strength is associated with knee symptoms but not with radiographic disease stage of osteoarthritis - data from the Osteoarthritis Initiative.
Arthritis Care and Research (Hoboken) 66:1344-1353 (2014)
Dannhauer T, Sattler M, Wirth W, Hunter DJ, Kwoh CK, Eckstein F
Longitudinal sensitivity to change of MRI-based muscle cross-sectional area versus isometric strength analysis in osteoarthritic knees with and without structural progression: pilot data from the Osteoarthritis Initiative.
Magnetic Resonance Materials in Physics, Biology and Medicine 27:339-347 (2014)
Eckstein F, Hitzl W, Duryea J, Kent Kwoh C, Wirth W; OAI investigators
Baseline and longitudinal change in isometric muscle strength prior to radiographic progression in osteoarthritic and pre-osteoarthritic knees - data from the Osteoarthritis Initiative.
Osteoarthritis and Cartilage 21:682-690 (2013)
Ruhdorfer A, Dannhauer T, Wirth W, Hitzl W, Kwoh CK, Guermazi A, Hunter DJ, Benichou
O, Eckstein F
Thigh muscle cross-sectional areas and strength in advanced versus early painful osteoarthritis-An exploratory between-knee, within-person comparison in osteoarthritis initiative participants.
Arthritis Care and Research 65:1034-1042 (2013)
Sattler M, Dannhauer T, Hudelmaier M, Wirth W, Sänger AM, Kwoh CK, Hunter DJ, Eckstein
Side differences of thigh muscle cross-sectional areas and maximal isometric muscle force in bilateral knees with the same radiographic disease stage, but unilateral frequent pain - Data from the Osteoarthritis Initiative.
Osteoarthritis and Cartilage 20:532-540 (2012)
Hudelmaier M, Wirth W, Himmer M, Ring-Dimitriou S, Sänger A, Eckstein F
Effect of exercise intervention on thigh muscle volume and anatomical cross-sectional areas-Quantitative assessment using MRI.
Magnetic Resonance in Medicine 64:1713-1720 (2010)
Cotofana S, Hudelmaier M, Wirth W, Himmer M, Ring-Dimitriou S, Sänger AM, Eckstein
Correlation between single-slice muscle anatomical cross-sectional area and muscle volume in thigh extensors, flexors and adductors of perimenopausal women.
European Journal of Applied Physiology 110:91-79 (2010)
Gratzke C, Hudelmaier M, Hitzl W, Glaser C, Eckstein F
Knee cartilage morphologic characteristics and muscle status of professional weight lifters and sprinters: a magnetic resonance imaging study.
American Journal of Sports Medicine 35:1346-1353 (2007)
Hudelmaier M, Glaser C, Hausschild A, Burgkart R, Eckstein F
Effects of joint unloading and reloading on human cartilage morphology and function, muscle cross-sectional areas, and bone density - a quantitative case report.
Journal of Musculoskeletal Neuronal Interaction: 6: 284-290 (2006)
Hudelmaier M, Glaser C, Hohe J, Englmeier KH, Reiser M, Putz R, Eckstein F
Correlation of knee joint cartilage morphology with muscle cross-sectional areas versus anthropometric variables.
Anatomical Record 270: 175-184 (2003)
Fürst D, Senck S, Hollensteiner M, Esterer B, Augat P, Eckstein F, Schrempf A
Characterization of synthetic foam structures used to manufacture artificial vertebral trabecular bone
Materials Science and Engineering: C Materials for Biological Applications 76:1103-1111 (2017)
Hudelmaier M, Wirth W
Differences in subchondral bone size after one year in osteoarthritic and healthy knees.
Osteoarthritis and Cartilage 24(2):623-630 (2016)
Pang J, Driban JB, Destenaves G, Miller E, Lo GH, Ward RJ, Price LL, Lynch JA, Eaton
CB, Eckstein F, McAlindon TE
Quantification of bone marrow lesion volume and volume change using semi-automated segmentation: data from the Osteoarthritis Initiative
BMC Musculoskeletal Disordorders 14:3 (2013)
Guermazi A, Hunter DJ, Li L, Benichou O, Eckstein F, Kwoh CK, Nevitt M, Hayashi D
Different thresholds for detecting osteophytes and joint space narrowing exist between the site investigators and the centralized reader in a multicenter knee osteoarthritis study-data from the Osteoarthritis Initiative.
Skeletal Radiology 41:179-186 (2012)
Eckstein F, Hudelmaier M, Cahue S, Marshall M, Sharma L
Medial-to-lateral ratio of tibiofemoral subchondral bone area is adapted to alignment and mechanical load.
Calcified Tissue International 84(3): 186-94 (2009)
Roemer FW, Kwoh CK, Hannon MJ, Hunter DJ, Eckstein F, Fujii T, Boudreau RM, Guermazi
What Comes First? Multitissue Involvement Leading to Radiographic Osteoarthritis: Magnetic Resonance Imaging-Based Trajectory Analysis Over Four Years in the Osteoarthritis Initiative.
Arthritis and Rheumatology 67:2085-2096 (2015)
Fotinos-Hoyer AK, Guermazi A, Jara H, Eckstein F, Ozonoff A, Khard H, Norbash A,
Bohndorf K, Roemer FW
Assessment of synovitis in the osteoarthritic knee: Comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast-enhanced fat-suppressed T(1)-weighted MRI.
Magnetic Resonance in Medicine 64(2):604-9 (2010)
Wachsmuth L, Lindhorst E, Wrubel S, Hadzhiyski H, Hudelmaier M, Eckstein F, Chrubasik
Micro-morphometrical assessment of the effect of harpagophytum procumbens extract on articular cartilage in rabbits with experimental osteoarthritis using magnetic resonance imging.
Phytotherapy Research 25:1133-1140 (2011)
Akshay is a Research Scientist at the Department of Radiology at Stanford University. Akshay graduated with a Ph.D. in Bioengineering from Stanford University in 2017 and B.S. from the University of California San Diego in 2012. He is interested intertwining medical imaging and computer science to develop biomedical imaging methodologies to better under physiology and to enhance the efficacy and efficiency of current diagnostic techniques. Akshay is currently combining deep learning and computer vision methods to advanced magnetic resonance imaging (MRI) data acquisition and signal processing techniques for generating rapid, quantitative and morphological magnetic resonance imaging (MRI) examinations. He seeks to develop such MR imaging techniques and implement them for diagnostic clinical imaging and in research studies evaluating early disease progression.
Akshay is experienced with hardware and software start-up companies. He previously was a consulting Technology and Application Specialist for Skope Magnetic Resonance Technologies and is currently a Deep Learning Research Scientist at Subtle Medical and also a scientific advisor for Brain Key.
Neal Bangerter is an Associate Professor of Bioengineering at Imperial College London. His current research interests include the application of artificial intelligence and machine learning to a variety of problems in medical imaging and healthcare, and the development of novel medical imaging technologies with a particular focus on musculoskeletal applications.
In addition to his research and teaching interests, Neal is passionate about innovation/entrepreneurship and intellectual property strategy. He regularly consults and advises in these areas. He has deep technical expertise in healthcare, medical imaging, machine learning, big data, signal processing, and software development, and significant management and strategy experience from his work in industry.Neal holds a BA with honors in Physics from UC-Berkeley and a Master’s and PhD in Electrical Engineering from Stanford University. He has held permanent and visiting positions at Oxford University, INSEAD, Brigham Young University, University of Utah, Microsoft, and management consulting firm McKinsey & Company.
|Name:||Mikael Ploug Boesen, MD, Ph.D.|
|Born:||May 27th 1971 in Copenhagen, Denmark|
|Work:||Bispebjerg and Frederiksberg Hospital, Deptof Radiology, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark|
|2017||Professor in musculoskeletal radiology at Copenhagen University and Bispebjerg and Frederiksberg Hospital|
|2015||Associate Professor in Radiology at Copenhagen University, Denmark|
|2014||Senior Consultant, head of musculoskeletal imaging and research, Dept. of Radiology, Bispebjerg and Frederiksberg Hospital|
|2009-2013||Head of MSK MRI research, Dept. of Radiology, Bispebjerg and Frederiksberg|
|2013||Specialist in Radiology, Consultant in Radiology, Dept. of Radiology Bispebjerg and Frederiksberg|
|2008||PhD degree entitled: “Magnetic Resonance Imaging of Joints Following Intra-articular Treatment and Procedures in Arthritis”|
|1999||Medical school graduation (Cand. Med.), University of Copenhagen|
I defended my PhD thesis in June 2008, entitled "Magnetic resonance imaging of joints following intra-articular treatment in arthritis" from the Parker Institute and Aalborg University. Throughout my radiology career I have pursued my special interest in advanced imaging of patients with various musculoskeletal conditions. My group and I have, specialised in quantification of cartilage changes as well as, soft tissue and bone inflammation in the joints with advanced imaging. We also serve as European reference centre for studies using a tilting open dedicated MRI unite – G-scan from ESAOTE, looking at the mechanical changes in the soft tissue, bone and cartilage in the spine, knee joints and feet going from supine to standing position.
Since 2008 I have been chairman of the IMAGINE group investigating DCE-MRI in patients with inflammatory arthritis, and I have co-organised several national and international imaging symposia’s and imaging courses, and have served as radiological specialist in the development of the national and international guidelines for imaging of degenerative and inflammatory joint and spinal diseases. I am an invited associate board member of the of the Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, MUSKRAD, ESSR, DRS, ESR, EULAR,OARSI, DIMS and I am part of the clinical and scientific advisory board of Image Analysis Group, London UK since 2010, where I have served as chairman until January 2019. Recently I have joined the scientific advisory board member of Chondrometrics, GmbH, Ainring, Germany in February 2019.
|Jan 2014-||Senior Consultant, head of musculoskeletal imaging and research, Dept. of Radiology, Bispebjerg and Frederiksberg Hospital, Copenhagen Denmark|
|2010-2018||Head of clinical and research advisory board Image Analysis Group (IAG), London, UK|
|2007-||Head of MSK MRI research, Dept. of Radiology, and Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen Denmark|
CEO, IAG, Image Analysis Group strategic imaging company supporting development of novel drugs
Managing Partner, IAG Bio-Partnering, is an independent investment division of IAG working with innovative life science companies at various stages of clinical development to support their drug development efforts through clinical trials to market entry
Investment Venture Partner, Analytics Ventures Fund, Artificial Intelligence and Machine Learning innovations focused San Diego based fund
Scientific Advisory Board Member for CureMatch, a biotechnology company, developing platform to match the right cure to the right patient (TBC)
Scientific Advisory Board Member for Chondrometrics GmbH, a leading provider of quantitative image analysis of articular tissues to researchers in academia and in the pharmaceutical industry.
Chondrometrics GmbH has a close partnership with Paracelsus Medical University, PMU, a private medical school in Austria founded in 2003. By tight integration with the Institute of Anatomy and Musculoskeletal Research, Chondrometrics and its employees maintain their roots in academic research, providing the company with a strong basis for innovation and validation of quantitative imaging biomarkers. The University's namesake Paracelsus (1493-1541) was a visionary pioneer of modern medicine and organic chemistry, who lived in Salzburg for parts of his life.
Chondrometrics GmbH also formed a strategic alliance and close collaboration with Boston Imaging Core Lab, BICL LLC in 2009, in order to broaden and advance the capability for offering imaging biomarker analysis to osteoarthritis researchers in academia and the pharmaceutical industry. BICL was founded in June 2007 by three Academic Radiologists from Boston University Medical Center, Boston, MA and is a leading provider of semi-quantitative radiological reading services for joint tissues affected by osteoarthritis, based on advanced radiological scoring systems. BICL's president, Dr Ali Guermazi, also is Section Chief of Musculoskeletal Radiology at the Department of Radiology, Boston University School of Medicine.
Together, both companies offer a comprehensive portfolio of quantitative and semi-quantitative imaging biomarkers, to permit their clients to detect risk factors in clinical trials with higher efficiency and to accelerate the development of disease modifying drugs, particularly for osteoarthritis and other joint diseases.
Team members of Chondrometrics GmbH were involved in creating several covers of renowned journals like for example the award winning journal cover of the inaugural issue of O&C open, the official publication organ of the Osteoarthritis Research Society International (OARSI).