Eckstein F, Maschek S, Roemer FW, Duda GN, Sharma L, Wirth W
Cartilage loss in radiographically normal knees depends on radiographic status of the contralateral knee - data from the Osteoarthritis Initiative.
Osteoarthritis and Cartilage. 2018

Deveza LA, Downie A, Tamez-Peña JG, Eckstein F, Van Spil WE, Hunter DJ
Trajectories of femorotibial cartilage thickness among persons with or at risk of knee osteoarthritis: development of a prediction model to identify progressors.
Osteoarthritis and Cartilage. 2018

Meng T, Venn A, Eckstein F, Wirth W, Cicuttini F, March L, Dwyer T, Cross M, Laslett LL, Jones G, Ding C, Antony B
Association of adiposity measures in childhood and adulthood with knee cartilage thickness, volume and bone area in young adults.
International journal of obesity and related metabolic disorders (Epub ahead of print)

Bricca A, Wirth W, Juhl CB, Kemnitz J, Hunter DJ, Kwoh CK, Eckstein F, Culvenor A
Moderate physical activity may prevent cartilage loss in women with knee osteoarthritis: data from the Osteoarthritis Initiative.

Arthritis Care and Research (Epub ahead of print)

Jafarzadeh SR, Clancy M, Li JS, Apovian CM, Guermazi A, Eckstein F, Felson DT

Changes in the structural features of osteoarthritis in a year of weight loss.

Osteoarthritis and Cartilage 26(6):775-782 (2018)

Chaudhari AS, Black MS, Eijgenraam S, Wirth W, Maschek S, Sveinsson B, Eckstein F, Oei EHG, Gold GE, Hargreaves BA
Five-minute knee MRI for simultaneous morphometry and T(2) relaxometry of cartilage and meniscus and for semiquantitative radiological assessment using double-echo in steady-state at 3T.

Journal of Magnetic Resonance Imaging 47(5):1328-1341 (2018)

Wirth W, Hunter DJ, Nevitt MC, Sharma L, Kwoh CK, Ladel C, Eckstein F

Predictive and concurrent validity of cartilage thickness change as a marker of knee osteoarthritis progression: data from the Osteoarthritis Initiative.
Osteoarthritis and Cartilage 25(12): 2063-2071 (2017)

Buck RJ, Le Graverand MH, Wirth W, Eckstein F

Choice of knee cartilage thickness change metric for different treatment goals in efficacy studies.
Seminars in Arthritis and Rheumatism 46(4):404-410 (2017)

van der Woude JAD, Wiegant K, van Roermund PM, Intema F, Custers RJH, Eckstein F, van Laar JM, Mastbergen SC, Lafeber FPJG
Five-year follow-up of knee joint distraction: clinical benefit and cartilaginous tissue repair in an open uncontrolled prospective study.
Cartilage 8(3):263-271 (2017)

Wirth W, Maschek S, Eckstein F

Sex- and age-dependence of region- and layer-specific knee cartilage composition (spin-spin-relaxation time) in healthy reference subjects.
Annals of Anatomy 210:1-8 (2017)

Moyer R, Wirth W, Eckstein F

Longitudinal changes in MRI-based measures of femorotibial cartilage thickness as a function of alignment and obesity data from the OAI.
Arthritis Care and Research 69(7):959-965 (2017)


Wirth W, Maschek S, Roemer FW, Eckstein F

Layer-specific femorotibial cartilage T2 relaxation time in knees with and without early knee osteoarthritis:Data from the Osteoarthritis Initiative (OAI).
Scientific Reports 6:34202 (2016)

Kwee RM, Wirth W, Hafezi-Nejad N, Zikria BA, Guermazi A, Demehri S

Role of physical activity in cartilage damage progression of subjects with baseline full-thickness cartilage defects in medial tibiofemoral compartment: data from the Osteoarthritis Initiative.

Osteoarthritis and Cartilage 24(11):1898-1904 (2016)


Roemer FW, Aydemir A, Lohmander S, Crema MD, Marra MD, Muurahainen N, Felson DT, Eckstein F, Guermazi A

Structural effects of sprifermin in knee osteoarthritis: a post-hoc analysis on cartilage and non-cartilaginous tissue alterations in a randomized controlled trial.

BMC Musculoskeletal Disorders 17:267 (2016)


van der Woude JA, van Heerwaarden RJ, Spruijt S, Eckstein F, Maschek S, van Roermund PM, Custers RJ, van Spil WE, Mastbergen SC, Lafeber FP

Six weeks of continuous joint distraction appears sufficient for clinical benefit and cartilaginous tissue repair in the treatment of knee osteoarthritis.

Knee 23(5):785-791(2016)


Roemer FW, Kwoh CK, Hannon MJ, Hunter DJ, Eckstein F, Grago J, Boudreau RM, Englund M, Guermazi A Partial meniscectomy is associated with increased risk of  incident radiographic osteoarthritis and worsening cartilage damage in the following year.

European Radiology 27(1):404-413 (2016)


Moyer R, Wirth W, Duryea J, Eckstein F

Anatomical alignment, but not goniometry, predicts femorotibial cartilage loss as well as mechanical alignment.

Data from the Osteoarthritis Initiative.

Osteoarthritis and Cartilage 24(2):254-261 (2016)


Eckstein F, Boudreau R, Wang Z, Hannon MJ, Duryea J, Wirth W, Cotofana S, Guermazi A, Roemer F, Nevitt M, John MR, Ladel C, Sharma L, Hunter DJ, Kwoh CK; OAI Investigators

Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: A longitudinal case-control study from the Osteoarthritis Initiative.

European Radiology 26(6):1942-1951(2016)


Huang C, Shan L, Charles C, Wirth W, Niethammer M, Zhu H

Diseased region detection of longitudinal knee magnetic resonance imaging data.

IEEE Transactions on Medical Imaging 34:1914-1912 (2015)


Eckstein F, Collins JE, Nevitt MC, Lynch JA, Kraus V, Katz JN, Losina E, Wirth W, Guermazi A, Roemer FW, Hunter DJ; FNIH OA Biomarkers Consortium

Cartilage thickness change as an imaging biomarker of knee osteoarthritis progression - data from the OA biomarkers consortium.

Arthritis and Rheumatology 67: 3184-3189 (2015)


Ried JS, Flechsenhar K, Bartnik E, Crowther D, Dietrich A, Eckstein F

Sample size calculations for detecting DMOAD effects on knee replacement in clinical trials - data from the Osteoarthritis Initiative.

Arthritis and Rheumatology 67:3174-3183 (2015)

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